On, 100% of the time when not playing. Off when playing. I have mine in a very well lit room that receives tons of natural light, I keep a very clean house but the amount of dust that attracts to the TT is unreal.
I leave mine open but attached. It leans against a wall and is only joined to the turntable by flimsy rubber tabs, so I don't think it has any real negative effect on SQ.