Neverending Covid-19 Coronavirus

Stupid robot check...

Anyways this article is about how people cured of COVID-19 are flaring back up with it in South Korea. Studies are going on now to determine why and how.

Right now it is believed that the virus can flare back up making you sick again rather than people catching the virus again.

This is realy scary if you think about it.

If it's anything like HIV, Herpes, chicken pox and what not, it may be possible to get flare ups later life. Like how chicken pox causes shingles. Herpes can cause cold sores.

As someone who had chickenpox as a kid and had 2 flare ups of shingles before the end of college (which doctors told me was rare and probably linked to my anxiety issues), fuuuuck this.
 
Our local university hospital laid off 900 people, including some nurses, others have had their hours and/or pay cut 15-20%.
Wow, so it's definitely happening. That's gotta be tough to swallow for the people that are frontline through this.

Our healthcare system is not built to handle situations like this.

Maybe this can inspire some real change?
 
Stupid robot check...

Anyways this article is about how people cured of COVID-19 are flaring back up with it in South Korea. Studies are going on now to determine why and how.

Right now it is believed that the virus can flare back up making you sick again rather than people catching the virus again.

This is realy scary if you think about it.

If it's anything like HIV, Herpes, chicken pox and what not, it may be possible to get flare ups later life. Like how chicken pox causes shingles. Herpes can cause cold sores.
As someone who had chickenpox as a kid and had 2 flare ups of shingles before the end of college (which doctors told me was rare and probably linked to my anxiety issues), fuuuuck this.
The evidence for this is anecdotal at best. SARS-CoV-2 is a single stranded, positive sense RNA virus, which hijacks the cellular machinery (ribosomes) to produce its own proteins and enzymes directly, including viral RNA polymerase which duplicates additional strands of RNA that are subsequently translated into viral proteins. There is no DNA stage, which would require transportation to the nucleus for transcription and is how DNA viruses (herpes/chickenpox/etc) and retroviruses (HIV) end up getting incorporated into the host genome. No integration of viral DNA means the chances of later recurrences or 'flare ups' is negligible. RNA just doesn't stick around that long in the cell.

Current model for SARS-CoV-2 replication:
nKPyZItR8vSTjPARPA-RKzAiighxYUdEYDBOdUbPkVHsrNanEm8Iu1_94qOutsdAhwKx8ukoVS8KSlCfciiP42-pgmsu-2ER23GNzYVfVMKCReNZvD-kSZhZotDqbcULNkyxpijcaXk
 
The evidence for this is anecdotal at best. SARS-CoV-2 is a single stranded, positive sense RNA virus, which hijacks the cellular machinery (ribosomes) to produce its own proteins and enzymes directly, including viral RNA polymerase which duplicates additional strands of RNA that are subsequently translated into viral proteins. There is no DNA stage, which would require transportation to the nucleus for transcription and is how DNA viruses (herpes/chickenpox/etc) and retroviruses (HIV) end up getting incorporated into the host genome. No integration of viral DNA means the chances of later recurrences or 'flare ups' is negligible. RNA just doesn't stick around that long in the cell.

Current model for SARS-CoV-2 replication:
nKPyZItR8vSTjPARPA-RKzAiighxYUdEYDBOdUbPkVHsrNanEm8Iu1_94qOutsdAhwKx8ukoVS8KSlCfciiP42-pgmsu-2ER23GNzYVfVMKCReNZvD-kSZhZotDqbcULNkyxpijcaXk

I .... have NO idea what you just said. But it sounded impressive.
 
The evidence for this is anecdotal at best. SARS-CoV-2 is a single stranded, positive sense RNA virus, which hijacks the cellular machinery (ribosomes) to produce its own proteins and enzymes directly, including viral RNA polymerase which duplicates additional strands of RNA that are subsequently translated into viral proteins. There is no DNA stage, which would require transportation to the nucleus for transcription and is how DNA viruses (herpes/chickenpox/etc) and retroviruses (HIV) end up getting incorporated into the host genome. No integration of viral DNA means the chances of later recurrences or 'flare ups' is negligible. RNA just doesn't stick around that long in the cell.

Current model for SARS-CoV-2 replication:
nKPyZItR8vSTjPARPA-RKzAiighxYUdEYDBOdUbPkVHsrNanEm8Iu1_94qOutsdAhwKx8ukoVS8KSlCfciiP42-pgmsu-2ER23GNzYVfVMKCReNZvD-kSZhZotDqbcULNkyxpijcaXk
100% this plus I have heard similar rumors bandied about the interweb suggesting different stains and people catching it twice, etc...

In all actuality the testing for the Novel virus has never been 100% accurate, the most likely scenario was people who tested positive early on received a false positive and then likely once they thought they were better laxed on their social distancing and then actually got Covid-19.
 
I .... have NO idea what you just said. But it sounded impressive.
Okay, viruses are what are known as obligate parasites. In other words, their entire lifecycle is dependent on stealing resources/tools/energy from other forms of life. They can't reproduce on their own; billions of years of evolution favored the loss of that ability. Evolutionarily, the question of life answered by viruses is, "Why bother to make your own reproductive tools when you can steal the energy, tools (enzymes), and materials (amino acids/nucleotides) from someone else who will do all the work for you?"

To make an analogy (loosely), you can think of viruses as hijackers or, more accurately, agents of industrial espionage. They work their way into a production facility (the cell) and, in a variety of ways, trick the factory into making the tools they need to hijack other factories in the same way.

Some viruses just feed their code into the machines and manufacturing tools (ribosomes) directly, which start spitting out the components of more viruses (viral genome/proteins/etc) instead of what they were supposed to produce (normal cellular proteins and enzymes.) This is how coronaviruses work. The cellular machinery will only make more viruses if the directions to do so are present. The directions, in the form of RNA are transient and prone to damage, so they only last as long as the virus is physically present, or not much longer.

Other hijackers (viruses) are less direct. Instead of hijacking the machinery directly, they insert their code into the bank of blueprints and instructions stored in the facility that controls production throughout the entire cellular factory (DNA in the nucleus.) By adding their DNA (directly or indirectly) to the genetic code in the nucleus, they ensure that whenever the cellular machinery activates that portion of DNA, the viral DNA will get copied, transcribed to RNA, and translated into proteins by the ribosomes. Even if the virus isn't present in a persons' body, the DNA it added to the genome IS, and will be for the entire lifetime of that cell and all its descendants. In fact, anywhere from 5-8% of the total DNA in your body is the defective/nonfunctional remains of viral hijackings (by retroviruses, specifically) in your evolutionary history. These infections can be chronic, recurring, or dormant for decades and then get 'reactivated' when something (like stress, or other disease) triggers the activation of that DNA. Retroviruses and DNA viruses work this way; think HIV and Herpes viruses (of all sorts, including chicken pox).
 
Okay, viruses are what are known as obligate parasites. In other words, their entire lifecycle is dependent on stealing resources/tools/energy from other forms of life. They can't reproduce on their own; billions of years of evolution favored the loss of that ability. Evolutionarily, the question of life answered by viruses is, "Why bother to make your own reproductive tools when you can steal the energy, tools (enzymes), and materials (amino acids/nucleotides) from someone else who will do all the work for you?"

To make an analogy (loosely), you can think of viruses as hijackers or, more accurately, agents of industrial espionage. They work their way into a production facility (the cell) and, in a variety of ways, trick the factory into making the tools they need to hijack other factories in the same way.

Some viruses just feed their code into the machines and manufacturing tools (ribosomes) directly, which start spitting out the components of more viruses (viral genome/proteins/etc) instead of what they were supposed to produce (normal cellular proteins and enzymes.) This is how coronaviruses work. The cellular machinery will only make more viruses if the directions to do so are present. The directions, in the form of RNA are transient and prone to damage, so they only last as long as the virus is physically present, or not much longer.

Other hijackers (viruses) are less direct. Instead of hijacking the machinery directly, they insert their code into the bank of blueprints and instructions stored in the facility that controls production throughout the entire facility (DNA in the nucleus.) By adding their DNA (directly or indirectly) to the genetic code in the nucleus, they ensure that whenever the cellular machinery activates that portion of DNA, the viral DNA will get copied, transcribed to RNA, and translated into proteins by the ribosomes. Even if the virus isn't present in a persons' body, the DNA it added to the genome IS, and will be for the entire lifetime of that cell and all its descendants. In fact, anywhere from 5-8% of the total DNA in your body is the defective/nonfunctional remains of viral hijackings (by retroviruses, specifically) in your evolutionary history. These infections can be chronic, recurring, or dormant for decades and then get 'reactivated' when something (like stress, or other disease) triggers the activation of that DNA. Retroviruses and DNA viruses work this way; think HIV and Herpes viruses (of all sorts, including chicken pox).
10/10. Would watch this movie based on synopsis alone 😎
 
the case fatality rate was 0.37%.
Man, the only downside of Germany having such an exceptional CFR is that it's gonna give the you-know-whos some ideas about why you guys have fared so well.
billions of years of evolution
Okay can you explain this again but this time in a model where Earth is only 6000 years old? I mean, it's Easter.
Jesus_Dino_WW.jpg
 
100% this plus I have heard similar rumors bandied about the interweb suggesting different stains and people catching it twice, etc...

In all actuality the testing for the Novel virus has never been 100% accurate, the most likely scenario was people who tested positive early on received a false positive and then likely once they thought they were better laxed on their social distancing and then actually got Covid-19.

The 56 people in South Korea who had flare ups all not only tested positive, they were sick. They were considered recovered when the virus was no longer detected in their system and yet they became sick again and tested positive again.

So it sounds more like it was people who were actually sick rather than false positives.

They are researching it further. This is not a rumor, it's from the CDC of Korea. Lot's of unknowns still. But the research is still in progress.
 
Man, the only downside of Germany having such an exceptional CFR is that it's gonna give the you-know-whos some ideas about why you guys have fared so well.

Okay can you explain this again but this time in a model where Earth is only 6000 years old? I mean, it's Easter.
Jesus_Dino_WW.jpg
There ate a couple of poins why germans fatality rate is so low in thiis ny times article
There are a couple of intersting points including the idea of regular tests for medical personnel. They always do one test for 10 nurses and only run individual tests if that comes up positive.
Secondly, doctors going out visiting patients with mild symptoms after a couple of days to see if tgey are about to get better or deteriorate and in the latter case directly admit to a hospital. And the main thing: tests , tests , tests.

What i see, what is not mentioned is the luck that we are 2-3 weeks behind italy and spain . It gave us time and the willingness to prepare and take social distancing measures earlier in the curve.
Now i hope, that german politicians shed their fear of right-wing populists and stop blocking corona-bonds to help italy and spain financially.
 
There are a couple of intersting points including the idea of regular tests for medical personnel. They always do one test for 10 nurses and only run individual tests if that comes up positive.
Secondly, doctors going out visiting patients with mild symptoms after a couple of days to see if tgey are about to get better or deteriorate and in the latter case directly admit to a hospital. And the main thing: tests , tests , tests.
giphy.gif
 
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